The family of pro-hormone and pro-protein convertases.

نویسندگان

  • N G Seidah
  • R Day
  • M Chrétien
چکیده

R. 1’. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 6388-6392 38. FourniC-Zaluski? M. C., Chaillet, P., Rouboutou, R., Coulaud, A., ChCrot, P., Waksman, G., Costentin, J. and Roques, B. P. (1984) Eur. J. Pharmacol. 102, 525-528 39. Hourgoin, S., I,e Hars, D., Artaud, F., Clot, A. M., Bouboutou, R., FourniC-Zaluski, M. C., Roques, B. P., Hamon, M. and Cesselin. F. (1986) J. Pharmacol. Exp. Ther. 238,360-366 40. FourniC-Zaluski, M. C., Coric, P., Turcaud, S., Lucas, E., Noble, F., Maldonado, R. and Roques, R. P. (1992) J. Med. Chem. 35,2474-2481 41. Soleilhac, J. M., I,ucas, E., Beaumont, A., Turcaud, S., Michel, J. R., Crine, P., FourniC-Zaluski, M. C. and Roques, R. I). (1992) Mol. Pharmacol. 41,609-614 42. Kahn, J. C., Patey, M., Dubois-Rande, J. L., Merlet, P., Castaigne, A., 1,im-Alexandre, C., Lecomte, J. M., Duboc, D., Gros. C. and Schwartz, J. C. (1 990) Lancet 335. 118-119 43. Noble, F.. Soleilhac, J. M., Lucas-Soroca, E., Turcaud, S., Fournid-Zaluski, M. C. and Hoques, B. 1’. (1 992) J. Pharmacol. Exp. Ther. 261, 18 1 190 44. Noble, F., Turcaud, S., FourniC-Zaluski, M. C. and Roques, B. P. (1992) Eur. J. Pharmacol. 223, 83-89 45. Noble, F., Coric, P., Fournie-Zaluski, M. C. and Roques, B. P. (1992) Eur. J. Pharmacol. 223,91-96 46. DaugC, V., Kalivas, P. W., Duffy, T. and Roques, B. P. ( 1992) Brain Res. 599,209-2 14 47. Baamonde, A,, DaugC, V., Ruiz-Gayo, M., Fulga, I. G., Turcaud, S., Fournik-Zaluski, M. C. and Roques, B. P. (1992) Neuropharmacology 29,215-223 48. Kromer, E. P., Elsmer, D., Kahles, H. W. and Riegger, G. A. (1991) Am. J. Hypertens. 4,460-461 49. Seymour, A. A,, Swerdel, J. N. and Abboa-Offei, B. (1991) J. Cardiovasc. Pharmacol. 17,456-465 50. Pham, I., Gonzalez, W., El Amrani, A. I. K., FournitiZaluski, M. C., Philippe, M., Laboulandine, I., Roques, B. P. and Michel, J. B. (1993) J. Pharmacol. Exp. Ther., in the press 68 5

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism.

The prohormone convertases (PCs), PC1/3 and PC2, are involved in the tissue-specific endoproteolytic posttranslational processing of many hormonal precursors within the secretory pathway. One important prohormone, pro-thyrotropin-releasing hormone (TRH), is expressed in both hypophysiotropic (where it regulates the secretion of thyroid-stimulating hormone) and nonhypophysiotropic regions of the...

متن کامل

Cap analog and Potato virus A HC-Pro silencing suppressor improve GFP transient expression using an infectious virus vector in Nicotiana benthamiana

Transient expression of proteins in plants has become a choice to facilitate recombinant protein production with its fast and easy application. On the other hand, host defensive mechanisms have been reported to reduce the efficiency of transient expression in plants. Hence, this study was designed to evaluate the effect of cap analog and Potato virus A helper component proteinase (PVA HC-Pro) o...

متن کامل

In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor.

The cleavage of parathyroid hormone (PTH) from its precursor proparathyroid hormone (pro-PTH) is accomplished efficiently by the proprotein convertase furin (Hendy, G. N., Bennett, H. P. J., Gibbs, B. F., Lazure, C., Day, R., and Seidah, N. G. (1995) J. Biol. Chem. 270, 9517-9525). We also showed that a synthetic peptide comprising the -6 to +7 sequence of human pro-PTH is appropriately cleaved...

متن کامل

Cellular localization of the prohormone convertases in the hypothalamic paraventricular and supraoptic nuclei: selective regulation of PC1 in corticotrophin-releasing hormone parvocellular neurons mediated by glucocorticoids.

The prohormone convertases (PCs) are processing enzymes that activate proproteins via cleavage at specific single or pairs of basic residues. The hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON) are primary sites of biosynthesis of several neuroendocrine hormone precursors, including provasopressin (pro-AVP), pro-oxytocin (pro-OT), and procorticotrophin-releasing hormone ...

متن کامل

Copeptin,as a new Boimarker

everything that disturbs the homeostatic balance of the body can be defined as stress and any stress factor activating the hypothalamic- pituitary-adrenal (HPA) axis causes an increase in arginine vasopressin (AVP) plasma concentrations. AVP is a 9 amino acid peptide in the ring structure and derived from pre-pro vasopressin. Pre-pro vasopressin is a pro hormone that synthesized by supraoptic ...

متن کامل

Tumor Necrosis Factor alpha, N-terminal Pro Brain Natriuretic Peptide and Interleukin-6 Correlations with Doppler Tissue Imaging findings in Major Thalassemia Patients

  Background   In respect to abnormalities in thalassemia patients and the effects of TNF_α, IL_6, and NT-pro-BNP on echocardiography findings the study aimed to investigate TNF_α, NT-pro-BNP and IL_6 correlations wit...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Biochemical Society transactions

دوره 21 ( Pt 3) 3  شماره 

صفحات  -

تاریخ انتشار 1993